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Structure of 52833-63-3
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2-Fluoro-N-methylbenzamide features a fluorinated aromatic ring paired with an N-methylamide group, delivering enhanced metabolic stability and improved membrane permeability. This combination enables efficient integration into bioactive scaffolds for medicinal chemistry campaigns, particularly in CNS-targeted drug discovery where electron-withdrawing fluorine substitution modulates both potency and pharmacokinetic profiles.
2-Fluoro-N-methylbenzamide serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated aromatic scaffolds. Its ortho-fluorine facilitates directed metallation and subsequent functionalization, while the N-methyl amide group offers enhanced metabolic stability and favorable lipophilicity. The compound exhibits excellent bench stability and is compatible with standard coupling reactions, facilitating efficient incorporation into complex molecular architectures.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P280-P304+P340-P405-P501
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Lot numbers can be found on the outside label of a product: