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CS-W001157 4
Total: USD 88.00

2-Fluoro-N-methylbenzamide

  • CAS No. 52833-63-3

  • Cat. No. CS-0141018
  • Purity≥98%
  • MDL No.MFCD01214098

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-N-methylbenzamide|CS-0141018

Structure of 52833-63-3

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General Information

  • CAS No. 52833-63-3
  • Cat. No. CS-0141018
  • Purity ≥98%
  • MDL No. MFCD01214098
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈FNO
  • Molecular Weight 153.15
  • Synonym(s) None
  • SMILES O=C(C1=CC=CC=C1F)NC

Description

2-Fluoro-N-methylbenzamide features a fluorinated aromatic ring paired with an N-methylamide group, delivering enhanced metabolic stability and improved membrane permeability. This combination enables efficient integration into bioactive scaffolds for medicinal chemistry campaigns, particularly in CNS-targeted drug discovery where electron-withdrawing fluorine substitution modulates both potency and pharmacokinetic profiles.

Application

2-Fluoro-N-methylbenzamide serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated aromatic scaffolds. Its ortho-fluorine facilitates directed metallation and subsequent functionalization, while the N-methyl amide group offers enhanced metabolic stability and favorable lipophilicity. The compound exhibits excellent bench stability and is compatible with standard coupling reactions, facilitating efficient incorporation into complex molecular architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P280-P304+P340-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   1.1853
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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