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CS-W001157 4
Total: USD 88.00

6-Bromo-2,3-dihydro-1H-indene-1-carboxylic acid

  • CAS No. 52651-16-8

  • Cat. No. CS-W022454
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Bromo-2,3-dihydro-1H-indene-1-carboxylic acid|CS-W022454

Structure of 52651-16-8

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General Information

  • CAS No. 52651-16-8
  • Cat. No. CS-W022454
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉BrO₂
  • Molecular Weight 241.08
  • Synonym(s) None
  • SMILES O=C(C1CCC2=C1C=C(Br)C=C2)O

Description

6-Bromo-2,3-dihydro-1H-indene-1-carboxylic acid features a brominated indene core with a carboxylic acid handle, enabling direct functionalization in synthetic routes. The electron-deficient aryl bromide facilitates cross-coupling reactions, while the saturated indene ring offers enhanced stability and solubility under standard conditions. This compound serves as a versatile intermediate for medicinal chemistry and materials synthesis.

Application

6-Bromo-2,3-dihydro-1H-indene-1-carboxylic acid serves as a versatile building block in medicinal chemistry and synthetic organic chemistry. Its structure combines a brominated aromatic ring with a carboxylic acid functional group, enabling facile Suzuki-Miyaura coupling and derivatization via esterification or amide formation. The molecule exhibits good bench stability and facilitates access to substituted indene scaffolds commonly found in bioactive molecules.

Synthesis

  • Route1

    References

    • Syntex (U.S.A.) Inc. Patent: US4957914 A1, 1990 ; US 4957914 A

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.5635
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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