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CS-W001157 4
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5-Bromo-2,3-dimethoxypyridine

  • CAS No. 52605-98-8

  • Cat. No. CS-0114153
  • Purity≥97%
  • MDL No.MFCD11052853

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2,3-dimethoxypyridine|CS-0114153

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General Information

  • CAS No. 52605-98-8
  • Cat. No. CS-0114153
  • Purity ≥97%
  • MDL No. MFCD11052853
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BrNO₂
  • Molecular Weight 218.05
  • Synonym(s) 2,3-dimethoxy5-bromopyridine
  • SMILES COC1=CC(Br)=CN=C1OC

Description

5-Bromo-2,3-dimethoxypyridine is a bench-stable pyridine derivative featuring two methoxy groups flanking a bromine at the 5-position. This electronic configuration enables efficient coupling in cross-coupling reactions, particularly in Suzuki-Miyaura and Stille transformations. The ortho-methoxy substituents enhance solubility and stabilize reactive intermediates during catalytic processes.

Application

5-Bromo-2,3-dimethoxypyridine serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions due to its well-defined halogen reactivity. The dimethoxy groups enhance solubility and stabilize the pyridine core under reaction conditions. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient synthesis of complex heterocyclic scaffolds, including those found in kinase inhibitors and advanced organic semiconductors.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   31.35
  • LogP   1.8613
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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