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CS-W001157 4
Total: USD 88.00

2-Chloro-3-methoxypyridine

  • CAS No. 52605-96-6

  • Cat. No. CS-W003068
  • Purity≥96%
  • MDL No.MFCD03426022

*For research and further manufacturing use only, not for direct human use.

2-Chloro-3-methoxypyridine|CS-W003068

Structure of 52605-96-6

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General Information

  • CAS No. 52605-96-6
  • Cat. No. CS-W003068
  • Purity ≥96%
  • MDL No. MFCD03426022
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆ClNO
  • Molecular Weight 143.57
  • Synonym(s) None
  • SMILES COc1cccnc1Cl

Description

2-Chloro-3-methoxypyridine features a pyridine core with orthogonal chlorine and methoxy substituents, enabling selective functionalization in heterocyclic synthesis. This bench-stable, moisture-tolerant building block integrates readily into pharmaceutical intermediates and agrochemical scaffolds via cross-coupling or nucleophilic substitution reactions.

Application

2-Chloro-3-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-established reactivity at the C2 position. The methoxy group at C3 provides orthogonal functionality for selective transformations, while the chloropyridine moiety offers excellent bench stability and compatibility with standard synthetic workflows. This compound facilitates efficient construction of heterocyclic scaffolds commonly found in pharmaceutical development.

Synthesis

  • Route1
    • In-stock
      2-Chloro-3-pyridinol|CS-D0978
      6636-78-8
    • null|null
      74-88-4
    • ~94%
    • In-stock
      2-Chloro-3-methoxypyridine|CS-W003068
      52605-96-6

    References

    • Yang, Junfeng; Liu, Sijia; Zheng, Jian-Feng; Zhou, Jianrong European Journal of Organic Chemistry, 2012 , # 31 p. 6248 - 6259,12 Title/Abstract Full Text Show Details Yang, Junfeng; Liu, Sijia; Zheng, Jian-Feng; Zhou, Jianrong European Journal of Organic Chemistry, 2012 , # 31 p. 6248 - 6259
  • Route2
    • null|null
      74-88-4
    • ~%
    • In-stock
      2-Chloro-3-methoxypyridine|CS-W003068
      52605-96-6

    References

    • BIONUMERIK PHARMACEUTICALS, INC. Patent: WO2007/123995 A2, 2007 ; Location in patent: Page/Page column 40 ;
  • Route3

    References

    • Ohta, Akihiro; Takahashi, Nobuhiro; Shirokoma, Yasuko Heterocycles, 1990 , vol. 30, # 2 p. 875 - 884

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.7436
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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