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CS-W001157 4
Total: USD 88.00

3-Methylindole-2-carboxaldehyde

  • CAS No. 5257-24-9

  • Cat. No. CS-0041558
  • Purity≥97%
  • MDL No.MFCD00957066

*For research and further manufacturing use only, not for direct human use.

3-Methylindole-2-carboxaldehyde|CS-0041558

Structure of 5257-24-9

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General Information

  • CAS No. 5257-24-9
  • Cat. No. CS-0041558
  • Purity ≥97%
  • MDL No. MFCD00957066
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉NO
  • Molecular Weight 159.18
  • Synonym(s) 3-Methylindole-2-carbaldehyde
  • SMILES O=CC(N1)=C(C)C2=C1C=CC=C2

Description

3-Methylindole-2-carboxaldehyde features a fused indole core with a methyl group at the 3-position and an aldehyde functional group at the 2-position, enabling direct integration into heterocyclic synthesis. The electron-rich indole system pairs with the reactive aldehyde for efficient coupling reactions. This compound serves as a key building block in medicinal chemistry and materials science.

Application

3-Methylindole-2-carboxaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to indole-based scaffolds through standard aldehyde functional group transformations. Its bench-stable nature and compatibility with amine coupling, reductive amination, and nucleophilic addition reactions facilitate straightforward synthesis of bioactive heterocycles. The molecule functions effectively in multistep sequences where orthogonality and predictable reactivity are essential for target-oriented synthesis.

Synthesis

  • Route1
    • null|null
      103865-85-6
    • ~99%
    • In-stock
      3-Methylindole-2-carboxaldehyde|CS-0041558
      5257-24-9

    References

    • Wilson, R. Marchall; Hengge, Alvan Journal of Organic Chemistry, 1987 , vol. 52, # 13 p. 2699 - 2707
  • Route2
    • (3-Methyl-1H-indol-2-yl)methanol|CS-1239252
      33186-56-0
    • ~84%
    • In-stock
      3-Methylindole-2-carboxaldehyde|CS-0041558
      5257-24-9

    References

    • Dethe, Dattatraya H.; Erande, Rohan D.; Ranjan, Alok Journal of Organic Chemistry, 2013 , vol. 78, # 20 p. 10106 - 10120
  • Route3
    • null|null
      164261-56-7
    • ~25%
    • In-stock
      3-Methylindole-2-carboxaldehyde|CS-0041558
      5257-24-9
    • null|null
      110396-65-1

    References

    • Mohanakrishnan, Arasambattu K.; Balamurugan, Ramalingam; Ramesh, Neelamegam Tetrahedron Letters, 2005 , vol. 46, # 47 p. 8189 - 8193

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H412
Precautionary Statements : P264-P270-P273-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.86
  • LogP   2.28882
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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