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CS-W001157 4
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1H-indazole-3-carbaldehyde

  • CAS No. 5235-10-9

  • Cat. No. CS-W019812
  • Purity≥97%
  • MDL No.MFCD04972468

*For research and further manufacturing use only, not for direct human use.

1H-indazole-3-carbaldehyde|CS-W019812

Structure of 5235-10-9

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General Information

  • CAS No. 5235-10-9
  • Cat. No. CS-W019812
  • Purity ≥97%
  • MDL No. MFCD04972468
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆N₂O
  • Molecular Weight 146.15
  • Synonym(s) 3-Indazolecarbaldehyde
  • SMILES O=CC1=NNC2=C1C=CC=C2

Description

1H-indazole-3-carbaldehyde features a reactive aldehyde group positioned at the 3-position of the indazole core, enabling direct coupling in multistep syntheses. This electron-deficient heterocycle integrates readily into bioactive scaffolds and serves as a key intermediate for pharmaceuticals and functional materials.

Application

1H-indazole-3-carbaldehyde serves as a versatile building block for heterocyclic synthesis, enabling efficient access to biologically relevant scaffolds. The aldehyde functionality facilitates straightforward derivatization via nucleophilic addition, reductive amination, and condensation reactions. Its stability under standard bench conditions and compatibility with common protecting groups support reliable integration into multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • US2006/142247 A1, ; Page/Page column 28 ;
  • Route2

    References

    • Tetrahedron, , vol. 63, # 2 p. 419 - 428
  • Route3
    • null|null
      887577-66-4
    • ~%
    • In-stock
      1H-indazole-3-carbaldehyde|CS-W019812
      5235-10-9

    References

    • Tetrahedron, , vol. 63, # 2 p. 419 - 428

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   45.75
  • LogP   1.3754
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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