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CS-W001157 4
Total: USD 88.00

4-Ethoxypyridin-2-amine

  • CAS No. 52311-20-3

  • Cat. No. CS-0005491
  • Molecule weight138.17
  • Purity≥97%
  • MDL No.MFCD01646350

*For research and further manufacturing use only, not for direct human use.

4-Ethoxypyridin-2-amine|CS-0005491

Structure of 52311-20-3

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General Information

  • CAS No. 52311-20-3
  • Cat. No. CS-0005491
  • Purity ≥97%
  • MDL No. MFCD01646350
  • Storage -20°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂O
  • Molecular Weight 138.17
  • Synonym(s) 2-Pyridinamine, 4-ethoxy-
  • SMILES CCOC1=CC(N)=NC=C1

Description

4-Ethoxypyridin-2-amine features a pyridine core functionalized with an ethoxy group at the 4-position and an amine at the 2-position, delivering enhanced solubility and reactivity. This scaffold integrates readily into pharmaceutical intermediates, leveraging its electron-rich nitrogen for coupling reactions. The molecule exhibits bench-stable handling under standard conditions.

Application

4-Ethoxypyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of pyridine-based scaffolds through standard coupling and functionalization reactions. Its ethoxy group provides enhanced solubility and handles well under common synthetic conditions, while the primary amine facilitates straightforward derivatization. The molecule exhibits good bench stability and is compatible with diverse reaction environments, making it ideal for use in multi-step synthesis workflows targeting bioactive heterocycles.

Synthesis

  • Route1

    References

    • Bijlsma; den Hertog Recueil des Travaux Chimiques des Pays-Bas, 1956 , vol. 75, p. 1187,1191

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.0625
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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