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CS-W001157 4
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2-Methylpyrimidine-5-carboxylic acid

  • CAS No. 5194-32-1

  • Cat. No. CS-W016511
  • Purity≥98%
  • MDL No.MFCD08235210

*For research and further manufacturing use only, not for direct human use.

2-Methylpyrimidine-5-carboxylic acid|CS-W016511

Structure of 5194-32-1

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General Information

  • CAS No. 5194-32-1
  • Cat. No. CS-W016511
  • Purity ≥98%
  • MDL No. MFCD08235210
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O₂
  • Molecular Weight 138.13
  • Synonym(s) 5-Pyrimidinecarboxylic acid, 2-methyl-
  • SMILES CC1=NC=C(C=N1)C(=O)O

Description

2-Methylpyrimidine-5-carboxylic acid features a pyrimidine core functionalized with a methyl group at the 2-position and a carboxylic acid at the 5-position, offering enhanced solubility and reactivity in synthetic transformations. This scaffold integrates readily into bioactive molecule design, particularly in medicinal chemistry applications where heterocyclic stability and polarity are critical.

Application

2-Methylpyrimidine-5-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its pyrimidine core provides structural rigidity and hydrogen-bonding capacity, while the carboxylic acid group facilitates amide formation, esterification, and derivatization under mild conditions. Bench-stable and readily purified by recrystallization, it functions effectively in multi-step syntheses requiring good functional group tolerance and predictable reactivity.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   0.48322
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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