(2-Fluorobenzyl)hydrazine

Name: (2-Fluorobenzyl)hydrazine
Brand: ChemScene
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CAS No. 51859-98-4
Cat. No. CS-0053072
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 51859-98-4

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Description

(2-Fluorobenzyl)hydrazine is a bench-stable hydrazine derivative featuring a fluorinated benzyl moiety, enabling selective functionalization in synthetic pathways. The electron-withdrawing fluorine substituent enhances reactivity while maintaining compatibility with diverse reaction conditions. This compound integrates readily into heterocyclic systems and serves as a key intermediate in medicinal chemistry applications requiring precise nitrogen incorporation.

Application

(2-Fluorobenzyl)hydrazine serves as a versatile building block in medicinal chemistry, enabling the construction of hydrazone-linked scaffolds through selective condensation with aldehydes and ketones. Its fluorinated aromatic ring enhances metabolic stability and modulates electronic properties, while the hydrazine moiety facilitates downstream transformations such as cyclization to heterocycles or oxidative cleavage. The compound exhibits good bench stability and is compatible with standard purification methods, making it suitable for high-throughput synthesis workflows.

General Information

CAS No. 51859-98-4
Cat. No. CS-0053072
Purity ≥95%
MDL No. None
Storage -20°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₉FN₂
Molecular Weight 140.16
Synonym(s) hydrazine, [(2-fluorophenyl)methyl]-
SMILES NNCC1=C(F)C=CC=C1

Computational Chemistry Data

TPSA 38.05
LogP 0.789
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2810
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Hydrazine

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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(2-Fluorobenzyl)hydrazine

CAS No. 51859-98-4

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