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Structure of 517920-73-9
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2-Fluoro-4-iodo-6-nitroaniline features a trifunctional aromatic core with strategically positioned fluorine, iodine, and nitro groups. This electron-deficient scaffold enables direct coupling in cross-coupling reactions, while the fluorine enhances metabolic stability. The iodine moiety serves as a high-reactivity handle for palladium-catalyzed transformations. This compound is bench-stable and compatible with standard synthetic protocols.
2-Fluoro-4-iodo-6-nitroaniline serves as a versatile building block in cross-coupling chemistry, enabling palladium-catalyzed reactions such as Suzuki-Miyaura and Buchwald-Hartwig couplings. The ortho-fluoro group enhances reactivity in nucleophilic aromatic substitution, while the iodo and nitro functionalities provide orthogonal handles for sequential functionalization. Its bench-stable nature and compatibility with standard purification methods make it well-suited for medicinal chemistry and API intermediate synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: