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N-(4-Hydroxyphenyl)methanesulfonamide

  • CAS No. 51767-39-6

  • Cat. No. CS-0116400
  • Molecule weight187.22
  • Purity≥98%
  • MDL No.MFCD00720883

*For research and further manufacturing use only, not for direct human use.

N-(4-Hydroxyphenyl)methanesulfonamide|CS-0116400

Structure of 51767-39-6

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General Information

  • CAS No. 51767-39-6
  • Cat. No. CS-0116400
  • Purity ≥98%
  • MDL No. MFCD00720883
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NO₃S
  • Molecular Weight 187.22
  • Synonym(s) 4-hydroxyphenyl methanesulphonamide
  • SMILES CS(=O)(NC1=CC=C(O)C=C1)=O

Description

N-(4-Hydroxyphenyl)methanesulfonamide features a phenolic hydroxyl group conjugated to an electron-deficient sulfonamide, enabling hydrogen bonding and enhanced solubility. This scaffold integrates readily into bioactive molecules, serving as a stable pharmacophore in kinase inhibitor design and drug metabolism studies.

Application

N-(4-Hydroxyphenyl)methanesulfonamide serves as a versatile building block in medicinal chemistry, enabling the introduction of both phenolic and sulfonamide functionalities in a single scaffold. Its hydroxyl group facilitates further derivatization via etherification or glucuronidation pathways, while the methanesulfonamide moiety provides metabolic stability and hydrogen-bonding capacity. The compound exhibits excellent bench stability and compatibility with standard coupling reactions, making it suitable for modular synthesis of bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   66.4
  • LogP   0.7637
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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