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CS-W001157 4
Total: USD 88.00

5-Hydroxypyridin-2(1H)-one

  • CAS No. 5154-01-8

  • Cat. No. CS-W006127
  • Purity≥98%
  • MDL No.MFCD00234075

*For research and further manufacturing use only, not for direct human use.

5-Hydroxypyridin-2(1H)-one|CS-W006127

Structure of 5154-01-8

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General Information

  • CAS No. 5154-01-8
  • Cat. No. CS-W006127
  • Purity ≥98%
  • MDL No. MFCD00234075
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅NO₂
  • Molecular Weight 111.10
  • Synonym(s) NSC 224189
  • SMILES O=C1C=CC(O)=CN1

Description

5-Hydroxypyridin-2(1H)-one delivers a potent chelating scaffold with enhanced solubility and stability under physiological conditions. This heterocyclic ligand features a phenolic hydroxyl group adjacent to a nitrogen-rich pyridine core, enabling strong coordination to transition metals. The compound exhibits excellent bench stability and moisture tolerance, making it ideal for use in metal-binding applications and bioconjugation workflows.

Application

5-Hydroxypyridin-2(1H)-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds through straightforward functionalization at the C5 hydroxyl and N1 positions. Its inherent stability under standard reaction conditions facilitates coupling reactions, derivatization, and incorporation into complex molecules. The compound exhibits favorable solubility and purification characteristics, making it well-suited for high-throughput synthesis and process development workflows.

Synthesis

  • Route1
    • α-Pyridone Levetiracetam Impurity|CS-0213990
      142-08-5
    • ~%
    • In-stock
      5-Hydroxypyridin-2(1H)-one|CS-W006127
      5154-01-8

    References

    • Journal of the American Chemical Society, , vol. 80, p. 3717
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 69, p. 1806
  • Route3
    • null|null
      99970-14-6
    • ~%
    • In-stock
      5-Hydroxypyridin-2(1H)-one|CS-W006127
      5154-01-8

    References

    • Journal of the American Chemical Society, , vol. 81, p. 6049,6053

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   53.09
  • LogP   0.0805
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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