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Structure of 5117-44-2
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2-(Pyrazin-2-yl)acetonitrile features a pyrazine ring linked to a nitrile-bearing acetyl side chain, delivering a robust heteroaromatic scaffold with enhanced electron-withdrawing character. This configuration enables efficient integration into synthetic routes requiring strong π-acidity or directional metal coordination. The molecule exhibits excellent stability under standard bench conditions and demonstrates favorable solubility in common organic solvents, streamlining its use in catalytic transformations and pharmaceutical intermediates.
2-(Pyrazin-2-yl)acetonitrile serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrazine-containing heterocycles via nucleophilic addition and cyclization reactions. Its nitrile group facilitates functionalization through hydrolysis or reduction, while the pyrazine core offers favorable metabolic stability and π-stacking interactions. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for use in multi-step synthesis campaigns targeting kinase inhibitors and other bioactive scaffolds.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501
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Lot numbers can be found on the outside label of a product: