Lot numbers can be found on the outside label of a product:
4-(5-Methyl-3-phenylisoxazol-4-yl)benzene-1-sulfonyl chloride
-
CAS No. 509074-26-4
- Cat. No. CS-0186875
- Purity≥97%
- MDL No.MFCD26385552
*For research and further manufacturing use only, not for direct human use.
Structure of 509074-26-4
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 509074-26-4
- Cat. No. CS-0186875
- Purity ≥97%
- MDL No. MFCD26385552
- Storage 4°C, sealed storage, away from moisture
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₆H₁₂ClNO₃S
- Molecular Weight 333.79
- Synonym(s) Benzenesulfonyl chloride, 4-(5-methyl-3-phenyl-4-isoxazolyl)-
- SMILES CC1=C(C(C2=CC=CC=C2)=NO1)C3=CC=C(S(=O)(Cl)=O)C=C3
Description
This sulfonyl chloride features a 4-(5-methyl-3-phenylisoxazol-4-yl)benzene scaffold, combining a sterically hindered isoxazole ring with a reactive sulfonyl chloride group. The electron-deficient aryl moiety enables efficient coupling in synthetic transformations, while the phenyl-substituted isoxazole enhances stability and solubility under standard conditions.
Application
4-(5-Methyl-3-phenylisoxazol-4-yl)benzene-1-sulfonyl chloride serves as a versatile building block for constructing sulfonamide-containing heterocycles. The isoxazole moiety provides structural rigidity and metabolic stability, while the sulfonyl chloride group enables facile derivatization via nucleophilic substitution. Its bench-stable nature and compatibility with common protecting groups facilitate integration into multi-step synthetic sequences, particularly in medicinal chemistry campaigns targeting kinase inhibitors and other bioactive scaffolds.
Synthesis
-
Route1
-
897927-43-4 - ~%
-
In-stock
509074-26-4
References
-
THAKASHINAMOORTHY, Chandiran; JESUDOSS, Mercy, Gnanadeepam; HARIHARASUBRAMANIAN, Meera; SEETHARAMAN, Subramanian, Sankara Patent: WO2005/85218 A1, 2005 ; Location in patent: Page/Page column 9 ;
-
-
Route2
-
In-stock
37928-17-9 - ~59%
-
In-stock
509074-26-4
References
-
Reddy, Anumula Raghupathi; Goverdhan, Gilla; Sampath, Aalla; Mukkanti, Khagga; Reddy, Padi Pratap; Bandichhor, Rakeshwar Synthetic Communications, 2012 , vol. 42, # 5 p. 639 - 649
-
-
Route3
-
181696-73-1 - ~%
-
In-stock
509074-26-4
References
-
Talley, John J.; Brown, David L.; Carter, Jeffery S.; Graneto, Matthew J.; Koboldt, Carol M.; Masferrer, Jaime L.; Perkins, William E.; Rogers, Roland S.; Shaffer, Alexander F.; Zhang, Yan Y.; Zweifel, Ben S.; Seibert, Karen Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 775 - 777
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS05
|
|
Signal Word : Danger
|
UN#: 3261
|
|
Class : 8
|
Packing Group : Ⅲ
|
|
Hazard Statements : H314
|
|
|
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 60.17
- LogP 4.24452
- H_Acceptors 4
- H_Donors 0
- Rotatable_Bonds 3
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 509074-26-4 sigma509074-26-4 manufacturer509074-26-4 price509074-26-4 structure509074-26-4 SDSbuy 509074-26-4509074-26-4 supplier509074-26-4 uses509074-26-4 molecular weightprice of 509074-26-4509074-26-4 chemical name formula of 509074-26-4