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CS-W001157 4
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(4-Fluoro-3-methoxyphenyl)methanamine

  • CAS No. 508177-67-1

  • Cat. No. CS-0063851
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4-Fluoro-3-methoxyphenyl)methanamine|CS-0063851

Structure of 508177-67-1

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General Information

  • CAS No. 508177-67-1
  • Cat. No. CS-0063851
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀FNO
  • Molecular Weight 155.17
  • Synonym(s) Benzenemethanamine, 4-fluoro-3-methoxy- (9CI)
  • SMILES NCC1=CC=C(F)C(OC)=C1

Description

This bench-stable arylamine features a para-fluoro and ortho-methoxy substitution pattern, delivering enhanced electron density and improved solubility in polar solvents. The amine moiety enables direct incorporation into pharmaceutical intermediates and functional materials via coupling reactions or electrophilic substitution.

Application

(4-Fluoro-3-methoxyphenyl)methanamine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-fluoro and meta-methoxy substituents provide favorable electronic and steric profiles for coupling reactions, while the primary amine functionality facilitates straightforward derivatization. The compound exhibits good bench stability and compatibility with standard purification techniques, making it well-suited for iterative synthetic workflows in API development.

Synthesis

  • Route1

    References

    • ELI LILLY AND COMPANY Patent: WO2005/66126 A1, 2005 ; Location in patent: Page/Page column 81-82 ; WO 2005/066126 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.293
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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