2-Amino-3-(2-chlorobenzoyl)-5-ethylthiophene

Name: 2-Amino-3-(2-chlorobenzoyl)-5-ethylthiophene
Brand: ChemScene
Availability: InStock
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CAS No. 50508-60-6
Cat. No. CS-0061451
Purity≥97%
MDL No.MFCD04107940

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2-Amino-3-(2-chlorobenzoyl)-5-ethylthiophene|CS-0061451

Structure of 50508-60-6

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General Information

CAS No. 50508-60-6
Cat. No. CS-0061451
Purity ≥97%
MDL No. MFCD04107940
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₂ClNOS
Molecular Weight 265.76
Synonym(s) 2-Amino-3-o-chlorobenzoyl-5-ethylthiophenefandachem
SMILES CCC1=CC(C(C2=CC=CC=C2Cl)=O)=C(S1)N

Description

2-Amino-3-(2-chlorobenzoyl)-5-ethylthiophene features a thiophene core functionalized with an electron-deficient benzoyl group and a pendant ethylthio substituent, enabling integration into bioactive heterocyclic scaffolds. This bench-stable compound facilitates synthesis of kinase inhibitors and fluorescent probes through its reactive amino and carbonyl sites.

Application

2-Amino-3-(2-chlorobenzoyl)-5-ethylthiophene serves as a versatile building block for the synthesis of biologically relevant thiophene derivatives. Its structure features an amino group at C2, a 2-chlorobenzoyl moiety at C3, and an ethylthiophene scaffold, enabling diverse functionalization. The molecule exhibits good bench stability and facilitates straightforward purification, making it suitable for use in medicinal chemistry campaigns targeting kinase inhibitors and other heterocyclic pharmaceuticals.

Synthesis

Route1
- In-stock
  
  40018-25-5
- 123-72-8
- ~55%
- In-stock
  
  50508-60-6
References
- Nagaoka, Hitoshi; Hara, Hiromu; Mase, Toshiyasu Heterocycles, 1990 , vol. 31, # 7 p. 1241 - 1244

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 43.09
LogP 3.7771
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Chloride

Building Blocks Functional Group Ketone

Building Blocks Skeleton Aromatic heterocycle compounds Thiophene compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-Amino-3-(2-chlorobenzoyl)-5-ethylthiophene

CAS No. 50508-60-6

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