Lot numbers can be found on the outside label of a product:
7-Bromo-2-naphthoic acid
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CAS No. 5043-14-1
- Cat. No. CS-0039508
- Purity≥95%
- MDL No.MFCD18410727
*For research and further manufacturing use only, not for direct human use.
Structure of 5043-14-1
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General Information
- CAS No. 5043-14-1
- Cat. No. CS-0039508
- Purity ≥95%
- MDL No. MFCD18410727
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₇BrO₂
- Molecular Weight 251.08
- Synonym(s) 2-Naphthalenecarboxylic acid,7-bromo
- SMILES O=C(C1=CC=C2C=CC(Br)=CC2=C1)O
Description
7-Bromo-2-naphthoic acid is a bench-stable, moisture-tolerant naphthalene derivative bearing a bromine substituent at the 7-position and a carboxylic acid group at the 2-position. This combination enables direct functionalization in cross-coupling reactions and facilitates conjugation to biomolecules or polymers via amide bond formation.
Application
7-Bromo-2-naphthoic acid serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization at the naphthalene core for pharmaceutical and materials applications. Its bromine substituent facilitates palladium-catalyzed cross-coupling reactions, while the carboxylic acid group supports derivatization via esterification, amidation, or decarboxylative transformations. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.
Synthesis
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Route1
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In-stock
58556-75-5 -
124-38-9 - ~85%
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In-stock
5043-14-1
References
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F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ALAM, Muzaffar; HAWLEY, Ronald Charles; LYNCH, Stephen M.; NARAYANAN, Arjun Patent: WO2014/86701 A1, 2014 ; Location in patent: Page/Page column 16 ;
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Route2
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In-stock
5159-63-7 - ~%
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In-stock
5043-14-1
References
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Gensini, Martina; Altamura, Maria; Dimoulas, Tula; Fedi, Valentina; Giannotti, Danilo; Giuliani, Sandro; Guidi, Antonio; Harmat, Nicholas J. S.; Meini, Stefania; Nannicini, Rossano; Pasqui, Franco; Tramontana, Manuela; Triolo, Antonio; Maggi, Carlo Alberto ChemMedChem, 2010 , vol. 5, # 1 p. 65 - 78
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Route3
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72775-49-6
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In-stock
5043-14-1
References
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Tsuno,Y. et al. Bulletin of the Chemical Society of Japan, 1979 , vol. 52, p. 3033 - 3042
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 37.3
- LogP 3.3005
- H_Acceptors 1
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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