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CS-W001157 4
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2-Methylpropan-1-amine hydrochloride

  • CAS No. 5041-09-8

  • Cat. No. CS-0154223
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Methylpropan-1-amine hydrochloride|CS-0154223

Structure of 5041-09-8

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General Information

  • CAS No. 5041-09-8
  • Cat. No. CS-0154223
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₂ClN
  • Molecular Weight 109.60
  • Synonym(s) Isobutylammonium Chloride
  • SMILES CC(C)CN.Cl

Description

2-Methylpropan-1-amine hydrochloride is a moisture-tolerant primary amine offering enhanced nucleophilicity and solubility in aqueous and polar organic media. This bench-stable derivative facilitates efficient amine incorporation in synthetic transformations, particularly in peptide coupling and catalytic alkylation reactions.

Application

2-Methylpropan-1-amine hydrochloride serves as a versatile primary amine building block in synthetic organic chemistry, enabling efficient amidation, urea formation, and nucleophilic substitution reactions. Its branched aliphatic structure provides enhanced solubility and stability in polar solvents, facilitating straightforward purification and handling in bench-scale synthesis. Widely used in medicinal chemistry and catalyst development, it functions effectively in both solution-phase and solid-phase workflows.

Synthesis

  • Route1
    • null|null
      102095-55-6
    • ~75%
    • In-stock
      2-Methylpropan-1-amine hydrochloride|CS-0154223
      5041-09-8

    References

    • Slusarska, Elzbieta; Zwierzak, Andrzej Liebigs Annalen der Chemie, 1986 , # 2 p. 402 - 405
  • Route2
    • null|null
      3416-17-9
    • ~%
    • In-stock
      2-Methylpropan-1-amine hydrochloride|CS-0154223
      5041-09-8

    References

    • Theodorou, Vassiliki; Ragoussis, Valentine; Strongilos, Alexandros; Zelepos, Evangelos; Eleftheriou, Argyro; Dimitriou, Maria Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1357 - 1360
  • Route3
    • null|null
      51411-27-9
    • ~%
    • In-stock
      2-Methylpropan-1-amine hydrochloride|CS-0154223
      5041-09-8

    References

    • Sampson, Peter B.; Honek, John F. Organic Letters, 1999 , vol. 1, # 9 p. 1395 - 1397

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.0229
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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