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Structure of 50390-76-6
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2-Methoxy-5-(methylsulfonyl)benzoic acid features a polar, electron-withdrawing methylsulfonyl group paired with a methoxy substituent, enhancing solubility and metabolic stability. This combination imparts strong hydrogen-bonding capacity and directional electronic effects, making it ideal for constructing bioactive scaffolds in medicinal chemistry and pharmaceutical process development.
2-Methoxy-5-(methylsulfonyl)benzoic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and drug-like scaffolds. Its orthogonal functional groups—carboxylic acid, methoxy, and methylsulfonyl—facilitate diverse downstream transformations, including amide coupling, Suzuki-Miyaura cross-coupling, and electrophilic substitution. The compound exhibits excellent bench stability and is readily purified by recrystallization, making it well-suited for high-throughput synthesis and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: