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CS-W001157 4
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2-(2-Pyridin-2-ylethyl)aniline

  • CAS No. 50385-28-9

  • Cat. No. CS-0530269
  • Purity≥96%
  • MDL No.MFCD05256417

*For research and further manufacturing use only, not for direct human use.

2-(2-Pyridin-2-ylethyl)aniline|CS-0530269

Structure of 50385-28-9

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General Information

  • CAS No. 50385-28-9
  • Cat. No. CS-0530269
  • Purity ≥96%
  • MDL No. MFCD05256417
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₄N₂
  • Molecular Weight 198.27
  • Synonym(s) None
  • SMILES NC1=CC=CC=C1CCC2=NC=CC=C2

Description

2-(2-(Pyridin-2-yl)ethyl)aniline features a conjugated linkage between an aromatic amine and a pyridyl ethyl spacer, enabling strong π-stacking and directional coordination. This structure facilitates integration into metal-ligand complexes and functional materials where electron density modulation is critical. The molecule exhibits enhanced solubility in organic solvents and stability under ambient conditions, supporting its use in catalytic systems and molecular scaffold design.

Application

2-(2-(Pyridin-2-yl)ethyl)aniline serves as a versatile bifunctional building block in medicinal chemistry, enabling the construction of biologically relevant heterocyclic scaffolds. Its pyridine and aniline moieties provide orthogonal reactivity for transition metal-catalyzed coupling reactions and functional group transformations. The molecule exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthesis workflows in API development and ligand design.

Synthesis

  • Route1
    • (E)-2-(2-nitrostyryl)pyridine|CS-0322464
      77340-84-2
    • ~%
    • 2-(2-Pyridin-2-ylethyl)aniline|CS-0530269
      50385-28-9

    References

    • Shaw; Wagstaff Journal of the Chemical Society, 1933 , p. 77
  • Route2
    • null|null
      5455-70-9
    • ~%
    • 2-(2-Pyridin-2-ylethyl)aniline|CS-0530269
      50385-28-9

    References

    • Hey; Osbond Journal of the Chemical Society, 1949 , p. 3172,3176
  • Route3
    • null|null
      109-06-8
    • ~%
    • 2-(2-Pyridin-2-ylethyl)aniline|CS-0530269
      50385-28-9

    References

    • Shaw; Wagstaff Journal of the Chemical Society, 1933 , p. 77

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.449
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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