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CS-W001157 4
Total: USD 88.00

5,6-Dimethoxypyrimidin-4-amine

  • CAS No. 5018-45-1

  • Cat. No. CS-0045622
  • Purity≥97%
  • MDL No.MFCD07787427

*For research and further manufacturing use only, not for direct human use.

5,6-Dimethoxypyrimidin-4-amine|CS-0045622

Structure of 5018-45-1

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General Information

  • CAS No. 5018-45-1
  • Cat. No. CS-0045622
  • Purity ≥97%
  • MDL No. MFCD07787427
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃O₂
  • Molecular Weight 155.15
  • Synonym(s) 5,6-dimethoxypyrimidin-4-ylamine
  • SMILES COC1=C(OC)C(N)=NC=N1

Description

5,6-Dimethoxypyrimidin-4-amine features two methoxy groups flanking a pyrimidine core, delivering enhanced solubility and stability under standard conditions. This electron-rich heterocycle integrates readily into medicinal chemistry scaffolds, serving as a key building block for kinase inhibitors and bioactive compounds requiring polar, bench-stable motifs.

Application

5,6-Dimethoxypyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its two methoxy groups enhance solubility and stability, while the amine functionality facilitates coupling reactions with electrophiles such as acyl chlorides, isocyanates, and activated esters. This compound functions effectively in parallel synthesis campaigns and offers predictable reactivity in standard amide and urea formation protocols, making it ideal for high-throughput screening libraries and API intermediate development.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      4-Amino-6-chloro-5-methoxypyrimidine|CS-0045688
      5018-41-7
    • ~93%
    • In-stock
      5,6-Dimethoxypyrimidin-4-amine|CS-0045622
      5018-45-1

    References

    • DEGUSSA AG Patent: WO2004/7466 A1, 2004 ; Location in patent: Page/Page column 7-8 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   70.26
  • LogP   0.076
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   2

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