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CS-W001157 4
Total: USD 88.00

DL-Histidine

  • CAS No. 4998-57-6

  • Cat. No. CS-W010925
  • Purity≥97%
  • MDL No.MFCD00005208

*For research and further manufacturing use only, not for direct human use.

DL-Histidine|CS-W010925

Structure of 4998-57-6

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General Information

  • CAS No. 4998-57-6
  • Cat. No. CS-W010925
  • Purity ≥97%
  • MDL No. MFCD00005208
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃O₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES NC(CC1=CNC=N1)C(O)=O

Description

DL-Histidine delivers a critical imidazole-containing amino acid essential for protein synthesis and metabolic regulation. This bench-stable compound integrates readily into peptide chains and serves as a key precursor in histamine biosynthesis, offering reliable performance in cell culture and biochemical assays under standard conditions.

Application

DL-Histidine serves as a vital building block in peptide synthesis and biochemical research, offering well-established reactivity at its imidazole side chain and α-amino/carboxyl groups. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient incorporation into synthetic peptides. The compound functions effectively in the construction of histidine-containing heterocycles and biologically relevant scaffolds, supporting diverse applications in medicinal chemistry and metabolic studies.

Synthesis

  • Route1

    References

    • Shiraiwa, Tadashi; Shinjo, Kazuyuki; Masui, Yoko; Ohta, Atsushi; Natsuyama, Hisashi; et. al. Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 12 p. 3741 - 3742
  • Route2
    • Acetylhistidine|CS-1169994
      10101-30-1
    • ~%
    • In-stock
      DL-Histidine|CS-W010925
      4998-57-6

    References

    • Albanese et al. Journal of Biological Chemistry, 1945 , vol. 160, p. 441,442 Full Text Show Details du Vigneaud; Hunt Journal of Biological Chemistry, 1936 , vol. 115, p. 93,97
  • Route3

    References

    • Ewins; Pyman Journal of the Chemical Society, 1911 , vol. 99, p. 344

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   92
  • LogP   -0.6359
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   3

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