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Structure of 497959-31-6
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This trifluoromethoxy-substituted benzaldehyde features a strategically positioned hydroxyl group, enabling direct participation in hydrogen bonding and facilitating downstream derivatization. The electron-withdrawing trifluoromethoxy moiety enhances electrophilicity at the carbonyl carbon, promoting reactivity in nucleophilic addition reactions. Bench-stable and moisture-tolerant, it serves as a key building block for bioactive heterocycles and functionalized aromatic scaffolds.
2-Hydroxy-3-(trifluoromethoxy)benzaldehyde serves as a versatile building block in medicinal chemistry and materials synthesis, enabling efficient access to bioactive heterocycles and functionalized aromatics. Its ortho-hydroxyl and trifluoromethoxy groups confer enhanced solubility and metabolic stability, while the aldehyde functionality facilitates reliable condensation reactions, including Ugi and Mannich-type transformations. Bench-stable and readily purified by recrystallization, it functions as a key intermediate in the construction of pharmaceutical scaffolds and fluorescent probes.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P233-P260-P261-P264-P271-P280-P302+P352-P304+P340-P340-P362-P403-P405-P501
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Lot numbers can be found on the outside label of a product: