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Structure of 93249-62-8
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2-Hydroxy-5-(trifluoromethoxy)benzaldehyde features a phenolic hydroxyl group and a strongly electron-withdrawing trifluoromethoxy substituent, creating a uniquely polarized aromatic system. This combination enhances reactivity in electrophilic substitution and facilitates coordination in transition metal catalysis. The molecule exhibits high stability under standard bench conditions and demonstrates favorable solubility in common organic solvents, enabling seamless integration into synthetic workflows for pharmaceutical intermediates and functional materials.
2-Hydroxy-5-(trifluoromethoxy)benzaldehyde serves as a versatile building block in medicinal chemistry and materials science, enabling the synthesis of functionalized heterocycles and bioactive scaffolds. Its ortho-hydroxyl and trifluoromethoxy groups confer enhanced solubility and metabolic stability, while the aldehyde functionality facilitates efficient condensation reactions, reductive amination, and imine formation under mild conditions. The compound exhibits good bench stability and is readily purified by crystallization or flash chromatography, making it well-suited for high-throughput synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: