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CS-W001157 4
Total: USD 88.00

2-Hydroxy-5-(trifluoromethoxy)benzaldehyde

  • CAS No. 93249-62-8

  • Cat. No. CS-W015351
  • Purity≥98%
  • MDL No.MFCD00075249
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Hydroxy-5-(trifluoromethoxy)benzaldehyde|CS-W015351

Structure of 93249-62-8

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Description

2-Hydroxy-5-(trifluoromethoxy)benzaldehyde features a phenolic hydroxyl group and a strongly electron-withdrawing trifluoromethoxy substituent, creating a uniquely polarized aromatic system. This combination enhances reactivity in electrophilic substitution and facilitates coordination in transition metal catalysis. The molecule exhibits high stability under standard bench conditions and demonstrates favorable solubility in common organic solvents, enabling seamless integration into synthetic workflows for pharmaceutical intermediates and functional materials.

Application

2-Hydroxy-5-(trifluoromethoxy)benzaldehyde serves as a versatile building block in medicinal chemistry and materials science, enabling the synthesis of functionalized heterocycles and bioactive scaffolds. Its ortho-hydroxyl and trifluoromethoxy groups confer enhanced solubility and metabolic stability, while the aldehyde functionality facilitates efficient condensation reactions, reductive amination, and imine formation under mild conditions. The compound exhibits good bench stability and is readily purified by crystallization or flash chromatography, making it well-suited for high-throughput synthetic workflows.

General Information

  • CAS No. 93249-62-8
  • Cat. No. CS-W015351
  • Purity ≥98%
  • MDL No. MFCD00075249
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅F₃O₃
  • Molecular Weight 206.12
  • Synonym(s) benzaldehyde, 2-hydroxy-5-(trifluoromethoxy)-
  • SMILES O=CC1=CC(OC(F)(F)F)=CC=C1O

Computational Chemistry Data

  • TPSA   46.53
  • LogP   2.1033
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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