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CS-W001157 4
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(2-Chloro-4-fluorophenyl)hydrazine hydrochloride

  • CAS No. 497959-29-2

  • Cat. No. CS-W003103
  • Purity≥97%
  • MDL No.MFCD03788524

*For research and further manufacturing use only, not for direct human use.

(2-Chloro-4-fluorophenyl)hydrazine hydrochloride|CS-W003103

Structure of 497959-29-2

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General Information

  • CAS No. 497959-29-2
  • Cat. No. CS-W003103
  • Purity ≥97%
  • MDL No. MFCD03788524
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇Cl₂FN₂
  • Molecular Weight 197.04
  • Synonym(s) 2-Chloro-4-fluorophenylhydrazine hydrochloride
  • SMILES NNc1ccc(cc1Cl)F.Cl

Description

(2-Chloro-4-fluorophenyl)hydrazine hydrochloride is a bench-stable hydrazine derivative featuring a strategically positioned chloro and fluoro substituent on the phenyl ring. This electronic tuning enhances reactivity in C–N bond-forming transformations, enabling efficient coupling with carbonyl electrophiles. The hydrochloride salt improves solubility and handling stability, streamlining integration into synthetic workflows for heterocyclic and pharmaceutical intermediates.

Application

(2-Chloro-4-fluorophenyl)hydrazine hydrochloride serves as a key building block in the synthesis of heterocyclic scaffolds, particularly for triazoles and imidazoles via cyclization reactions. Its well-defined reactivity enables efficient coupling with carbonyl derivatives and electrophiles under mild conditions. The compound exhibits good bench stability and facilitates straightforward purification, making it suitable for scalable medicinal chemistry campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   2.1865
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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