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CS-W001157 4
Total: USD 88.00

2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine

  • CAS No. 49669-14-9

  • Cat. No. CS-0153767
  • Purity≥95%
  • MDL No.MFCD12406888
  • HazMat Fee +

    HazMat Fee

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine|CS-0153767

Structure of 49669-14-9

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Description

2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine features a brominated pyridine core paired with a stable 2-methyl-1,3-dioxolane protecting group, enabling selective functionalization in cross-coupling reactions. The dioxolane moiety enhances solubility and stability under standard conditions, while the bromide serves as a reliable coupling handle for palladium-mediated transformations.

Application

2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient Pd-catalyzed transformations to access substituted pyridine scaffolds. The 1,3-dioxolan-2-yl group provides excellent stability and mild deprotection conditions, while the bromide facilitates reliable Suzuki, Stille, and Negishi couplings. Its bench-stable nature and compatibility with diverse functional groups make it ideal for iterative synthesis in medicinal chemistry and process development workflows.

General Information

  • CAS No. 49669-14-9
  • Cat. No. CS-0153767
  • Purity ≥95%
  • MDL No. MFCD12406888
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀BrNO₂
  • Molecular Weight 244.09
  • Synonym(s) None
  • SMILES CC1(C2=NC(=CC=C2)Br)OCCO1

Computational Chemistry Data

  • TPSA   31.35
  • LogP   2.0636
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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