Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

1-(Hydroxymethyl)cyclopropane carboxylic acid

  • CAS No. 49640-66-6

  • Cat. No. CS-0042329
  • Purity≥97%
  • MDL No.MFCD17078844

*For research and further manufacturing use only, not for direct human use.

1-(Hydroxymethyl)cyclopropane carboxylic acid|CS-0042329

Structure of 49640-66-6

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 49640-66-6
  • Cat. No. CS-0042329
  • Purity ≥97%
  • MDL No. MFCD17078844
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₈O₃
  • Molecular Weight 116.12
  • Synonym(s) 1-(Hydroxymethyl)cyclopropanecarboxylic acid
  • SMILES O=C(C1(CO)CC1)O

Description

1-(Hydroxymethyl)cyclopropane carboxylic acid features a rigid cyclopropane ring fused to a carboxylic acid and hydroxymethyl group, enabling unique stereochemical control in synthetic transformations. This scaffold delivers structural rigidity while maintaining functional group accessibility for derivatization.

Application

1-(Hydroxymethyl)cyclopropane carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the introduction of both a cyclopropyl ring and a functionalized hydroxymethyl group. Its stability under standard reaction conditions facilitates downstream transformations such as oxidation, esterification, and coupling reactions. The molecule functions effectively in the synthesis of bioactive scaffolds and chiral intermediates due to its well-defined stereochemistry and compatibility with diverse functional groups.

Synthesis

  • Route1

    References

    • ARDELYX, INC.; LEWIS, Jason, G.; REICH, Nicholas; CHEN, Tao; JACOBS, Jeffrey W.; CHARMOT, Dominique; NAVRE, Marc; FINN, Patricia; CARRERAS, Christopher; SPENCER, Andrew Patent: WO2013/96771 A1, 2013 ; Location in patent: Page/Page column 125 ;
  • Route2
    • Ethyl 2-bromocyclobutane-1-carboxylate|CS-0835486
      2983-89-3
    • ~%
    • In-stock
      1-(Hydroxymethyl)cyclopropane carboxylic acid|CS-0042329
      49640-66-6

    References

    • OSI PHARMACEUTICALS, INC. Patent: WO2006/17443 A2, 2006 ; Location in patent: Page/Page column 100 ; WO 2006/017443 A2
  • Route3

    References

    • Estieu, Karine; Ollivier, Jean; Salauen, Jacques Tetrahedron, 1998 , vol. 54, # 28 p. 8075 - 8090

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   57.53
  • LogP   -0.1565
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 49640-66-6 sigma49640-66-6 manufacturer49640-66-6 price49640-66-6 structure49640-66-6 SDSbuy 49640-66-649640-66-6 supplier49640-66-6 uses49640-66-6 molecular weightprice of 49640-66-649640-66-6 chemical name formula of 49640-66-6
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label