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CS-W001157 4
Total: USD 88.00

3-(4-Methyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoic acid

  • CAS No. 487-66-1

  • Cat. No. CS-0153465
  • Purity≥98%
  • MDL No.MFCD18252872

*For research and further manufacturing use only, not for direct human use.

3-(4-Methyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoic acid|CS-0153465

Structure of 487-66-1

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General Information

  • CAS No. 487-66-1
  • Cat. No. CS-0153465
  • Purity ≥98%
  • MDL No. MFCD18252872
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈O₅
  • Molecular Weight 184.15
  • Synonym(s) 3-Furanpropanoic acid, 2,5-dihydro-4-methyl-2,5-dioxo-
  • SMILES CC1=C(CCC(=O)O)C(=O)OC1=O

Description

This 3-(4-methyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoic acid features a reactive maleimide-like furanone core paired with a pendant propionic acid side chain. The molecule integrates readily into bioconjugation workflows, offering site-specific labeling potential through Michael addition reactions. Bench-stable and moisture-tolerant, it enables efficient coupling under physiological conditions.

Synthesis

  • Route1
    • null|null
      347406-12-6
    • ~94%
    • In-stock
      3-(4-Methyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoic acid|CS-0153465
      487-66-1

    References

    • Deshpande; Natu; Argade Synthesis, 2001 , # 5 p. 702 - 704
  • Route2
    • null|null
      496919-84-7
    • ~%
    • In-stock
      3-(4-Methyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoic acid|CS-0153465
      487-66-1

    References

    • Takemoto, Hiroyasu; Miyata, Kanjiro; Hattori, Shota; Ishii, Takehiko; Suma, Tomoya; Uchida, Satoshi; Nishiyama, Nobuhiro; Kataoka, Kazunori Angewandte Chemie - International Edition, 2013 , vol. 52, # 24 p. 6218 - 6221 Angew. Chem., 2013 , vol. 125, # 24 p. 6338 - 6341,4
  • Route3
    • null|null
      577-53-7
    • ~%
    • In-stock
      3-(4-Methyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoic acid|CS-0153465
      487-66-1

    References

    • Wang, Wenjun; Li, Lei; Jin, Chen; Niu, Yujie; Li, Sen; Ma, Ji; Li, Linfeng; Liu, Yu; Cai, Li; Zhao, Wei; Wang, Peng George Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 17 p. 5041 - 5044

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   80.67
  • LogP   0.2511
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

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