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Structure of 483-69-2
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5-(Trifluoromethyl)quinolin-8-amine features a trifluoromethyl group at the 5-position and an amino functionality at the 8-position of the quinoline scaffold. This electron-deficient heterocycle combines enhanced metabolic stability with favorable solubility characteristics, enabling direct incorporation into medicinal chemistry programs targeting kinase inhibition and CNS-penetrant drug discovery.
5-(Trifluoromethyl)quinolin-8-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its trifluoromethyl group enhances metabolic stability and membrane permeability, while the amine functionality facilitates direct derivatization or incorporation into pharmaceutical scaffolds via amidation, alkylation, or transition-metal-catalyzed cross-couplings. The compound exhibits good bench stability and is readily purified by chromatography or recrystallization, supporting scalable synthesis and integration into lead optimization campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: