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CS-W001157 4
Total: USD 88.00

1-Hydroxy-1H-pyrrole-2,5-dione

  • CAS No. 4814-74-8

  • Cat. No. CS-0327189
  • Molecule weight113.07
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Hydroxy-1H-pyrrole-2,5-dione|CS-0327189

Structure of 4814-74-8

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General Information

  • CAS No. 4814-74-8
  • Cat. No. CS-0327189
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃NO₃
  • Molecular Weight 113.07
  • Synonym(s) N-Hydroxymaleimide
  • SMILES C1=CC(=O)N(C1=O)O

Description

N-Hydroxymaleimide (NHMI) is an organic compound that is widely used as an oxidizing agent in organic synthesis. It is frequently used to selectively oxidize thiols to disulfides and in the synthesis of , -unsaturated carbonyl compounds. It can also act as a Michael acceptor and is used in the synthesis of peptides and proteins.N-Hydroxymaleimide can be used as an oxidant to generate N-hydroxy anilines in situ, which serve as key intermediates in the selective coupling reaction of N-substituted anilines with hydroxylamine derivatives, for the efficient synthesis of aromatic oximes.

Synthesis

  • Route1
    • null|null
      60361-89-9
    • ~79%
    • 1-Hydroxy-1H-pyrrole-2,5-dione|CS-0327189
      4814-74-8

    References

    • Akiyama, Masayasu; Shimizu, Kazuyuki; Aiba, Seiichi; Banba, Fumio Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2122 - 2125
  • Route2

    References

    • Akiyama, Masayasu; Shimizu, Kazuyuki; Aiba, Seiichi; Banba, Fumio Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2122 - 2125
  • Route3
    • Benzyl (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl) carbonate|CS-1150778
      58936-19-9
    • ~44%
    • 1-Hydroxy-1H-pyrrole-2,5-dione|CS-0327189
      4814-74-8

    References

    • Akiyama, Masayasu; Shimizu, Kazuyuki; Aiba, Seiichi; Banba, Fumio Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2122 - 2125

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   57.61
  • LogP   -0.6994
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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