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4-Methylpyridine-3-sulfonic acid

  • CAS No. 4808-71-3

  • Cat. No. CS-0043756
  • Purity≥97%
  • MDL No.MFCD00661349

*For research and further manufacturing use only, not for direct human use.

4-Methylpyridine-3-sulfonic acid|CS-0043756

Structure of 4808-71-3

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General Information

  • CAS No. 4808-71-3
  • Cat. No. CS-0043756
  • Purity ≥97%
  • MDL No. MFCD00661349
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO₃S
  • Molecular Weight 173.19
  • Synonym(s) 4-Methyl-3-pyridinesulfonic acid
  • SMILES O=S(C1=C(C)C=CN=C1)(O)=O

Description

4-Methylpyridine-3-sulfonic acid features a pyridine core with strategically positioned methyl and sulfonic acid groups, enabling strong solubility and enhanced acidity. This combination delivers robust performance in catalytic systems and as a synthetic intermediate under standard conditions.

Application

4-Methylpyridine-3-sulfonic acid serves as a versatile building block in medicinal chemistry and catalysis, offering a well-defined pyridyl scaffold with enhanced solubility due to the sulfonic acid group. Its methyl substituent provides a site for directed functionalization, while the acidic sulfonate moiety enables salt formation and improves chromatographic handling. The compound exhibits bench stability and functions effectively in cross-coupling reactions and heterocycle synthesis.

Synthesis

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      4-Methylpyridine-3-sulfonic acid|CS-0043756
      4808-71-3

    References

    • Webb; Corwin Journal of the American Chemical Society, 1944 , vol. 66, p. 1456,1458 Full Text Show Details McElvain; Goese Journal of the American Chemical Society, 1943 , vol. 65, p. 2233,2235 Full Text Show Details I. G. Farbenind. Patent: DE541036 , 1928 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 17, p. 2443

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   67.26
  • LogP   0.63672
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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