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CS-W001157 4
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6-Methylpyridine-3-sulfonic acid

  • CAS No. 4808-69-9

  • Cat. No. CS-W006199
  • Purity≥98%
  • MDL No.MFCD01646153

*For research and further manufacturing use only, not for direct human use.

6-Methylpyridine-3-sulfonic acid|CS-W006199

Structure of 4808-69-9

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General Information

  • CAS No. 4808-69-9
  • Cat. No. CS-W006199
  • Purity ≥98%
  • MDL No. MFCD01646153
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO₃S
  • Molecular Weight 173.19
  • Synonym(s) 6-Methylpyridine-3-sulfonicaci
  • SMILES C1=C([S](=O)(=O)O)C=NC(=C1)C

Description

6-Methylpyridine-3-sulfonic acid features a pyridine ring with methyl and sulfonic acid groups positioned at the 6- and 3-positions, respectively. This arrangement imparts strong acidity and enhanced solubility in aqueous systems. The molecule integrates readily into polar reaction environments, serving as a robust scaffold for functionalized heterocycles and polarity-modified intermediates in synthetic chemistry workflows.

Application

6-Methylpyridine-3-sulfonic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through its orthogonal reactivity profile. The sulfonic acid group provides strong acidity and solubility, while the methyl and pyridine functionalities support regioselective functionalization. This compound facilitates efficient derivatization in standard coupling and electrophilic substitution protocols, offering bench-stable access to substituted pyridine scaffolds relevant to pharmaceutical development.

Synthesis

  • Route1
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      109-06-8
    • ~%
    • In-stock
      6-Methylpyridine-3-sulfonic acid|CS-W006199
      4808-69-9

    References

    • McElvain; Goese Journal of the American Chemical Society, 1943 , vol. 65, p. 2233,2235 Full Text Show Details I. G. Farbenind. Patent: DE541036 , 1928 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 17, p. 2443
  • Route2
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      109-06-8
    • null|null
      7664-93-9
    • null|null
      7446-11-9
    • ~%
    • In-stock
      6-Methylpyridine-3-sulfonic acid|CS-W006199
      4808-69-9

    References

    • McElvain; Goese Journal of the American Chemical Society, 1943 , vol. 65, p. 2233,2235

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   67.26
  • LogP   0.63672
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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