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Structure of 20870-77-3
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4-Chloroindolin-2-one is a bench-stable heterocyclic scaffold featuring a chlorine substituent at the 4-position of the indolinone core. This electron-deficient moiety integrates readily into medicinal chemistry campaigns, serving as a key intermediate for kinase inhibitors and fluorescent probes due to its compatibility with diverse coupling reactions and structural rigidity.
4-Chloroindolin-2-one serves as a versatile building block in medicinal chemistry, enabling efficient access to indole-based heterocycles. Its electron-deficient aromatic core facilitates electrophilic substitution and transition-metal-catalyzed coupling reactions. The carbonyl group supports nucleophilic addition and condensation processes, while the chlorine substituent provides a handle for further functionalization via cross-coupling or displacement reactions. Bench-stable and readily purified, it functions effectively in multi-step syntheses of bioactive molecules and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: