Lot numbers can be found on the outside label of a product:
tert-Butyl 4-hydroxyhexahydro-1H-azepine-1-carboxylate
-
CAS No. 478832-21-2
- Cat. No. CS-D0037
- Purity≥96%
- MDL No.MFCD07368610
*For research and further manufacturing use only, not for direct human use.
Structure of 478832-21-2
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 478832-21-2
- Cat. No. CS-D0037
- Purity ≥96%
- MDL No. MFCD07368610
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₂₁NO₃
- Molecular Weight 215.29
- Synonym(s) Tert-butyl 4-hydroxyazepane-1-carboxylate
- SMILES O=C(N1CCC(O)CCC1)OC(C)(C)C
Description
tert-Butyl 4-hydroxyhexahydro-1H-azepine-1-carboxylate features a hydroxylated azepane core with a robust tert-butyl carbamate protecting group. This bench-stable, moisture-tolerant scaffold integrates readily into complex heterocyclic architectures, enabling efficient access to bioactive nitrogen-containing frameworks in medicinal chemistry and synthetic methodology.
Application
tert-Butyl 4-hydroxyhexahydro-1H-azepine-1-carboxylate serves as a versatile scaffold for the synthesis of nitrogen-containing heterocycles, leveraging its hydroxyl group for selective functionalization and the protected amine for downstream transformations. The tert-butyl carbamate handle enables straightforward deprotection under mild acidic conditions, while the saturated azepine ring offers conformational stability and compatibility with standard coupling and reduction protocols. Its bench-stable nature and ease of purification make it well-suited for medicinal chemistry and process development workflows.
Synthesis
-
Route1
-
109162-29-0 -
In-stock
34619-03-9 - ~67%
-
In-stock
478832-21-2
References
-
Sumitomo Pharmaceuticals Company, Limited Patent: EP1403255 A1, 2004 ; Location in patent: Page 93-94 ; EP 1403255 A1
-
-
Route2
-
In-stock
188975-88-4 - ~99%
-
In-stock
478832-21-2
References
-
ELI LILLY AND COMPANY Patent: WO2009/12125 A1, 2009 ; Location in patent: Page/Page column 30 ;
-
-
Route3
-
39888-51-2 -
In-stock
24424-99-5 - ~70%
-
In-stock
478832-21-2
References
-
Sumitomo Pharmaceuticals Company, Limited Patent: EP1500643 A1, 2005 ; Location in patent: Page 48 ; EP 1500643 A1
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 49.77
- LogP 1.7683
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 478832-21-2 sigma478832-21-2 manufacturer478832-21-2 price478832-21-2 structure478832-21-2 SDSbuy 478832-21-2478832-21-2 supplier478832-21-2 uses478832-21-2 molecular weightprice of 478832-21-2478832-21-2 chemical name formula of 478832-21-2