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CS-W001157 4
Total: USD 88.00

1-(1H-Indol-6-yl)ethanone

  • CAS No. 81223-73-6

  • Cat. No. CS-0060852
  • Purity≥97%
  • MDL No.MFCD09035921

*For research and further manufacturing use only, not for direct human use.

1-(1H-Indol-6-yl)ethanone|CS-0060852

Structure of 81223-73-6

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General Information

  • CAS No. 81223-73-6
  • Cat. No. CS-0060852
  • Purity ≥97%
  • MDL No. MFCD09035921
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉NO
  • Molecular Weight None
  • Synonym(s) Ethanone, 1-(1H-indol-6-yl)- (9CI)
  • SMILES CC(=O)C1=CC2=C(C=C1)C=CN2

Description

1-(1H-Indol-6-yl)ethanone features a fused indole core with a ketone group at the 6-position, enabling direct functionalization in synthetic transformations. This electron-deficient carbonyl moiety integrates readily into bioactive scaffolds and serves as a key intermediate in pharmaceutical and agrochemical synthesis.

Application

1-(1H-Indol-6-yl)ethanone serves as a versatile building block for the synthesis of indole-based pharmaceuticals and functional materials. Its ketone functionality enables direct nucleophilic addition, reductive amination, and olefination reactions under standard conditions. The molecule exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development.

Synthesis

  • Route1
    • 6-Acetyl-1H-indole-2-carboxylic acid|CS-0970944
      81223-71-4
    • ~78%
    • In-stock
      1-(1H-Indol-6-yl)ethanone|CS-0060852
      81223-73-6

    References

    • Kim, Phieo Ta; Guilard, Roger; Dodey, Pierre; Sornay, Roland Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1365 - 1371
  • Route2
    • null|null
      155703-10-9
    • ~94%
    • In-stock
      1-(1H-Indol-6-yl)ethanone|CS-0060852
      81223-73-6

    References

    • Cruz, Rosimeire P.A.; Ottoni, Olivia; Abella, Carlos A.M.; Aquino, Ligia B. Tetrahedron Letters, 2001 , vol. 42, # 8 p. 1467 - 1469
  • Route3
    • 2-(4-Bromophenyl)-2-methyl-1,3-dioxolane|CS-0193348
      4360-68-3
    • ~%
    • In-stock
      1-(1H-Indol-6-yl)ethanone|CS-0060852
      81223-73-6

    References

    • Journal of Heterocyclic Chemistry, , vol. 18, p. 1365 - 1371

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.86
  • LogP   2.3705
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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