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CS-W001157 4
Total: USD 88.00

(4'-Hydroxy-[1,1'-biphenyl]-4-yl)boronic acid

  • CAS No. 477760-86-4

  • Cat. No. CS-0059915
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4'-Hydroxy-[1,1'-biphenyl]-4-yl)boronic acid|CS-0059915

Structure of 477760-86-4

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General Information

  • CAS No. 477760-86-4
  • Cat. No. CS-0059915
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₁BO₃
  • Molecular Weight 214.02
  • Synonym(s) 4-(4-Hydroxyphenyl)phenylboronic acid
  • SMILES C=1(C=CC(=CC1)C2=CC=C(C=C2)B(O)O)O

Description

This boronate moiety integrates seamlessly into Suzuki-Miyaura cross-coupling reactions, delivering high functional group tolerance and stability under standard conditions. The para-hydroxy substituent enhances solubility in polar solvents and facilitates downstream derivatization.

Application

(4'-Hydroxy-[1,1'-biphenyl]-4-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds. The pendant hydroxyl group provides orthogonal functionality for further derivatization, while the boronic acid moiety exhibits excellent bench stability and compatibility with diverse reaction conditions. Its predictable reactivity and straightforward purification profile make it well-suited for medicinal chemistry and materials synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   0.739
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   2

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