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CS-W001157 4
Total: USD 88.00

Hygric acid

  • CAS No. 475-11-6

  • Cat. No. CS-B1517
  • Purity≥97%
  • MDL No.MFCD00011565

*For research and further manufacturing use only, not for direct human use.

Hygric acid|CS-B1517

Structure of 475-11-6

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General Information

  • CAS No. 475-11-6
  • Cat. No. CS-B1517
  • Purity ≥97%
  • MDL No. MFCD00011565
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁NO₂
  • Molecular Weight 129.16
  • Synonym(s) N-Methyl-L-proline
  • SMILES O=C(O)[C@H]1N(C)CCC1

Description

Hygric acid is a moisture-tolerant reagent featuring a robust, electron-deficient core that enables reliable coupling reactions under ambient conditions. This stable scaffold integrates seamlessly into synthetic workflows, delivering consistent yields without requiring anhydrous environments or specialized handling.

Application

Hygric acid serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of complex heterocyclic scaffolds through well-documented condensation and cyclization reactions. Its carboxylic acid and amine functionalities offer orthogonal reactivity, facilitating peptide coupling and amide bond formation under standard conditions. The compound exhibits excellent bench stability and is compatible with common protecting group strategies, making it a practical choice for iterative synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1
    • L-Proline Enalapril  Impurity|CS-0229432
      147-85-3
    • ~87%
    • In-stock
      Hygric acid|CS-B1517
      475-11-6

    References

    • Abbott Laboratories Patent: US5516912 A1, 1996 ;
  • Route2
    • null|null
      50-00-0
    • L-Proline Enalapril  Impurity|CS-0229432
      147-85-3
    • ~10%
    • In-stock
      Hygric acid|CS-B1517
      475-11-6

    References

    • Aurelio, Luigi; Box, John S.; Brownlee, Robert T. C.; Hughes, Andrew B.; Sleebs, Marianne M. Journal of Organic Chemistry, 2003 , vol. 68, # 7 p. 2652 - 2667
  • Route3
    • null|null
      124-38-9
    • null|null
      265660-44-4
    • ~%
    • In-stock
      Hygric acid|CS-B1517
      475-11-6
    • In-stock
      Hygric acid|CS-B1517
      475-11-6

    References

    • Gawley, Robert E.; Zhang, Qianhui Journal of the American Chemical Society, 1993 , vol. 115, # 16 p. 7515 - 7516

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.54
  • LogP   0.1652
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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