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Piperazine-1-carboxamide hydrochloride

  • CAS No. 474711-89-2

  • Cat. No. CS-0149933
  • Purity≥97%
  • MDL No.MFCD06408948

*For research and further manufacturing use only, not for direct human use.

Piperazine-1-carboxamide hydrochloride|CS-0149933

Structure of 474711-89-2

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General Information

  • CAS No. 474711-89-2
  • Cat. No. CS-0149933
  • Purity ≥97%
  • MDL No. MFCD06408948
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClN₃O
  • Molecular Weight 165.62
  • Synonym(s) None
  • SMILES NC(N1CCNCC1)=O.Cl

Description

Piperazine-1-carboxamide hydrochloride features a protonated piperazine core paired with a carboxamide functionality, delivering enhanced solubility and stability under standard conditions. This compound serves as a key scaffold in medicinal chemistry, integrating readily into diverse molecular architectures through its amide linkage and basic nitrogen sites.

Application

Piperazine-1-carboxamide hydrochloride serves as a versatile building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds. Its amide functionality offers enhanced solubility and hydrogen-bonding capacity, while the protonated piperazine ring ensures good stability and ease of purification. The compound functions effectively in standard coupling reactions and is compatible with common protecting group strategies, facilitating its use in multi-step syntheses of bioactive molecules.

Synthesis

  • Route1

    References

    • EP1593679 A1, ; Page/Page column 59 ; EP 1593679 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302+H312+H332-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.36
  • LogP   -0.6079
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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