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CS-W001157 4
Total: USD 88.00

4-Boc-(3-Hydroxymethyl)morpholine

  • CAS No. 473923-56-7

  • Cat. No. CS-W018561
  • Purity≥97%
  • MDL No.MFCD04038649

*For research and further manufacturing use only, not for direct human use.

4-Boc-(3-Hydroxymethyl)morpholine|CS-W018561

Structure of 473923-56-7

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General Information

  • CAS No. 473923-56-7
  • Cat. No. CS-W018561
  • Purity ≥97%
  • MDL No. MFCD04038649
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₉NO₄
  • Molecular Weight 217.26
  • Synonym(s) tert-Butyl-3-(hydroxymethyl)morpholin-4-carboxylat
  • SMILES OCC1N(C(OC(C)(C)C)=O)CCOC1

Description

4-Boc-(3-Hydroxymethyl)morpholine features a morpholine ring functionalized with a hydroxymethyl group and a robust Boc protecting group. This combination enables stable incorporation into complex synthetic sequences, where the alcohol moiety can be selectively manipulated post-deprotection. The Boc group ensures compatibility with standard deprotection conditions, streamlining access to the free amine for further derivatization.

Application

4-Boc-(3-Hydroxymethyl)morpholine serves as a versatile morpholine derivative enabling efficient construction of bioactive heterocycles. The Boc group provides excellent stability and ease of removal under mild acidic conditions, while the pendant hydroxymethyl functionality offers direct handle for oxidation, protection, or coupling reactions. This compound functions effectively in multi-step syntheses requiring orthogonal functional group manipulation and is well-suited for medicinal chemistry applications involving scaffold diversification and targeted derivatization.

Synthesis

  • Route1

    References

    • US2006/46984 A1, ; Page/Page column 25-26 ;
  • Route2
    • Di-Tert-butyl morpholine-3,4-dicarboxylate|CS-0769773
      1269446-63-0
    • ~99%
    • In-stock
      4-Boc-(3-Hydroxymethyl)morpholine|CS-W018561
      473923-56-7

    References

    • WO2009/71658 A1, ; Page/Page column 29 ; WO 2009/071658 A1
  • Route3

    References

    • WO2008/125570 A1, ; Page/Page column 47-48 ; WO 2008/125570 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   59
  • LogP   0.6146
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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