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CS-W001157 4
Total: USD 88.00

Oxalamide

  • CAS No. 471-46-5

  • Cat. No. CS-W016676
  • Purity≥95%
  • MDL No.MFCD00008007

*For research and further manufacturing use only, not for direct human use.

Oxalamide|CS-W016676

Structure of 471-46-5

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General Information

  • CAS No. 471-46-5
  • Cat. No. CS-W016676
  • Purity ≥95%
  • MDL No. MFCD00008007
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂H₄N₂O₂
  • Molecular Weight 88.07
  • Synonym(s) Oxamide
  • SMILES O=C(N)C(N)=O

Description

Azido-PEG3-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. Azido group will react with DBCO, BCN or other Alkyne group through click chemistry, PEG spacer increases aqueous solubility.

Application

Oxalamide serves as a stable, bench-ready building block for the construction of bioactive heterocycles and peptide-like scaffolds. Its dual amide functionality enables efficient coupling reactions with amines and alcohols under mild conditions, facilitating rapid diversification in medicinal chemistry campaigns. The molecule exhibits excellent solubility in common organic solvents and tolerates a range of functional groups, making it ideal for modular synthesis workflows requiring high reproducibility and straightforward purification.

Synthesis

  • Route1
    • null|null
      553-90-2
    • null|null
      67-56-1
    • ~98%
    • In-stock
      Oxalamide|CS-W016676
      471-46-5

    References

    • Ube Industries, Ltd. Patent: US6348626 B1, 2002 ; Location in patent: Page column 5 - 6, 7 - 8 ;
  • Route2
    • null|null
      201230-82-2
    • ~76%
    • In-stock
      Oxalamide|CS-W016676
      471-46-5

    References

    • Hiwatari, Kozo; Kayaki, Yoshihito; Okita, Koshi; Ukai, Tomohiro; Shimizu, Isao; Yamamoto, Akio Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 12 p. 2237 - 2250
  • Route3

    References

    • Mohammadpoor-Baltork, Iraj; Khodaei, Mohammad Mehdi; Nikoofar, Kobra Tetrahedron Letters, 2003 , vol. 44, # 3 p. 591 - 594

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS08,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H372-H411
Precautionary Statements : P260-P264-P270-P273-P330-P391-P501

Quality Control

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Computational Chemistry Data

  • TPSA   86.18
  • LogP   -2.043
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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