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Structure of 467451-91-8
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6-(Trifluoromethoxy)-1H-indole features a trifluoromethoxy group at the 6-position of the indole scaffold, conferring enhanced electron-withdrawing character and metabolic stability. This substitution pattern improves solubility in organic solvents and supports efficient incorporation into pharmaceutical intermediates. The molecule exhibits bench-stable handling properties and serves as a key building block for bioactive heterocycles in medicinal chemistry.
6-(Trifluoromethoxy)-1H-indole serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard electrophilic substitution and transition-metal-catalyzed coupling reactions. Its trifluoromethoxy group enhances metabolic stability and modulates lipophilicity, while the indole core provides a versatile scaffold for drug discovery. Bench-stable and readily purified, it functions effectively in diverse synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: