3,5-Difluoro-4-formylbenzonitrile

Name: 3,5-Difluoro-4-formylbenzonitrile
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 467442-15-5
Cat. No. CS-W000015
Purity≥98%
MDL No.MFCD08457661

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3,5-Difluoro-4-formylbenzonitrile|CS-W000015

Structure of 467442-15-5

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 467442-15-5
Cat. No. CS-W000015
Purity ≥98%
MDL No. MFCD08457661
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₃F₂NO
Molecular Weight 167.11
Synonym(s) None
SMILES Fc1cc(cc(F)c1C=O)C#N

Description

3,5-Difluoro-4-formylbenzonitrile features a trifunctional aromatic core with electron-withdrawing fluorine and nitrile groups flanking a formyl handle. This combination enables direct integration into diverse synthetic scaffolds, particularly in medicinal chemistry and materials science, where orthogonal reactivity and enhanced metabolic stability are critical.

Application

3,5-Difluoro-4-formylbenzonitrile serves as a versatile building block for the synthesis of fluorinated aromatic scaffolds. The formyl and nitrile groups enable diverse transformations, including nucleophilic additions, reductive aminations, and heterocycle formation. Its bench-stable nature and orthogonal functional group tolerance facilitate efficient multi-step synthesis in medicinal chemistry and agrochemical development.

Synthesis

Route1
- 433939-87-8
- ~99%
- In-stock
  
  467442-15-5
References
- ASTRAZENECA AB Patent: WO2003/101956 A1, 2003 ; Location in patent: Page 131 ; WO 03/101956 A1
Route2
- In-stock
  
  64248-63-1
- 68-12-2
- ~79%
- In-stock
  
  467442-15-5
References
- Olsen, Jacob; Seiler, Paul; Wagner, Bjoern; Fischer, Holger; Tschopp, Thomas; Obst-Sander, Ulrike; Banner, David W.; Kansy, Manfred; Mueller, Klaus; Diederich, Francois Organic and Biomolecular Chemistry, 2004 , vol. 2, # 9 p. 1339 - 1352

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 40.86
LogP 1.64898
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

3,5-Difluoro-4-formylbenzonitrile sigma3,5-Difluoro-4-formylbenzonitrile manufacturer3,5-Difluoro-4-formylbenzonitrile price3,5-Difluoro-4-formylbenzonitrile structure3,5-Difluoro-4-formylbenzonitrile SDSbuy 3,5-Difluoro-4-formylbenzonitrile3,5-Difluoro-4-formylbenzonitrile supplier3,5-Difluoro-4-formylbenzonitrile uses3,5-Difluoro-4-formylbenzonitrile molecular weightprice of 3,5-Difluoro-4-formylbenzonitrile3,5-Difluoro-4-formylbenzonitrile chemical name formula of 3,5-Difluoro-4-formylbenzonitrile

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

3,5-Difluoro-4-formylbenzonitrile

CAS No. 467442-15-5

Recommended Products