4'-Chloro-[1,1'-biphenyl]-3-carboxylic acid

Name: 4'-Chloro-[1,1'-biphenyl]-3-carboxylic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 4655-10-1
Cat. No. CS-0033713
Purity≥98%
MDL No.MFCD03426505

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4'-Chloro-[1,1'-biphenyl]-3-carboxylic acid|CS-0033713

Structure of 4655-10-1

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 4655-10-1
Cat. No. CS-0033713
Purity ≥98%
MDL No. MFCD03426505
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₉ClO₂
Molecular Weight 232.66
Synonym(s) 4'-Chlorobiphenyl-3-carboxylic acid
SMILES O=C(C1=CC(C2=CC=C(Cl)C=C2)=CC=C1)O

Description

4'-Chloro-[1,1'-biphenyl]-3-carboxylic acid features a chlorinated aryl group paired with a carboxylic acid functionality, enabling direct incorporation into pharmaceutical scaffolds. The para-chloro substitution enhances electron-withdrawing character and improves metabolic stability. This compound serves as a key intermediate in the synthesis of bioactive molecules requiring rigid, planar aromatic systems.

Application

4'-Chloro-[1,1'-biphenyl]-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of biaryl scaffolds via standard coupling reactions. Its carboxylic acid functionality facilitates direct derivatization into amides, esters, or acyl chlorides, while the ortho-chloro substituent provides a handle for subsequent cross-coupling or electrophilic functionalization. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis workflows in API development.

Synthesis

Route1
- In-stock
  
  1679-18-1
- In-stock
  
  618-51-9
- ~98%
- In-stock
  
  4655-10-1
References
- Lehmann, Fredrik; Currier, Erika A.; Clemons, Bryan; Hansen, Lars K.; Olsson, Roger; Hacksell, Uli; Luthman, Kristina Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 13 p. 4657 - 4665

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 37.3
LogP 3.7052
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

4655-10-1 sigma4655-10-1 manufacturer4655-10-1 price4655-10-1 structure4655-10-1 SDSbuy 4655-10-14655-10-1 supplier4655-10-1 uses4655-10-1 molecular weightprice of 4655-10-14655-10-1 chemical name formula of 4655-10-1

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4'-Chloro-[1,1'-biphenyl]-3-carboxylic acid

CAS No. 4655-10-1

Recommended Products