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CS-W001157 4
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2-(tert-Butylamino)ethan-1-ol

  • CAS No. 4620-70-6

  • Cat. No. CS-0214733
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(tert-Butylamino)ethan-1-ol|CS-0214733

Structure of 4620-70-6

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General Information

  • CAS No. 4620-70-6
  • Cat. No. CS-0214733
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₅NO
  • Molecular Weight 117.19
  • Synonym(s) N-tert-Butylethanolamine
  • SMILES CC(C)(C)NCCO

Description

This bench-stable amine-alcohol integrates seamlessly into peptide coupling and polymer functionalization workflows. The tert-butylamino group provides steric bulk and enhanced solubility, while the primary hydroxyl enables efficient derivatization under standard conditions.

Application

2-(tert-Butylamino)ethan-1-ol serves as a versatile bifunctional building block in synthetic chemistry, combining a stable tertiary amine with a primary alcohol. It facilitates the construction of amino-alcohol motifs prevalent in pharmaceutical intermediates and ligands. The tert-butyl group enhances steric bulk and metabolic stability, while the hydroxyl functionality enables derivatization via esterification or ether formation. Its bench-stable nature and compatibility with standard coupling conditions make it well-suited for multi-step synthesis and process-scale applications.

Synthesis

  • Route1
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      75-21-8
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      75-64-9
    • ~67%
    • In-stock
      2-(tert-Butylamino)ethan-1-ol|CS-0214733
      4620-70-6

    References

    • Plesch, Winfried; Wiessler, Manfred Liebigs Annalen der Chemie, 1984 , # 8 p. 1494 - 1503
  • Route2
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      627-11-2
    • null|null
      75-64-9
    • ~%
    • In-stock
      2-(tert-Butylamino)ethan-1-ol|CS-0214733
      4620-70-6

    References

    • Holmen; Carroll Journal of the American Chemical Society, 1951 , vol. 73, p. 1859
  • Route3
    • null|null
      7732-18-5
    • null|null
      75-64-9
    • ~%
    • In-stock
      2-(tert-Butylamino)ethan-1-ol|CS-0214733
      4620-70-6

    References

    • Bortnick et al. Journal of the American Chemical Society, 1956 , vol. 78, p. 4039,4040

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2923
Class : 8(6.1)
Packing Group : Ⅱ
Hazard Statements : H302-H311-H314-H318
Precautionary Statements : P260-P270-P280-P303+P361+P353-P305+P351+P338

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   0.3668
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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