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(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-methoxy-1H-indol-3-yl)propanoic acid

  • CAS No. 460751-69-3

  • Cat. No. CS-0169363
  • Purity≥97%
  • MDL No.MFCD28166522

*For research and further manufacturing use only, not for direct human use.

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-methoxy-1H-indol-3-yl)propanoic acid|CS-0169363

Structure of 460751-69-3

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General Information

  • CAS No. 460751-69-3
  • Cat. No. CS-0169363
  • Purity ≥97%
  • MDL No. MFCD28166522
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₇H₂₄N₂O₅
  • Molecular Weight 456.49
  • Synonym(s) N-Fmoc-5-methoxy-L-tryptophan
  • SMILES O=C(O)[C@H](CC1=CNC2=C1C=C(OC)C=C2)NC(OCC3C4=C(C5=C3C=CC=C5)C=CC=C4)=O

Description

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-methoxy-1H-indol-3-yl)propanoic acid is a chiral building block featuring a fluorenylmethoxycarbonyl (Fmoc) protected amino group and a 5-methoxyindole side chain. This configuration enables direct incorporation into peptide synthesis workflows, offering enhanced solubility and stability under standard conditions.

Application

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-methoxy-1H-indol-3-yl)propanoic acid serves as a valuable chiral building block for the synthesis of peptide-like scaffolds and bioactive heterocycles. The fluorenylmethoxycarbonyl (Fmoc) group enables efficient, orthogonal protection in solid-phase peptide synthesis, while the 5-methoxyindole moiety provides a stable, electron-rich aromatic handle for further functionalization. This compound exhibits excellent bench stability, facilitates straightforward purification via flash chromatography, and functions reliably in standard coupling protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   100.65
  • LogP   4.7109
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   7

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