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CS-W001157 4
Total: USD 88.00

3,6-Dimethoxypyridazine

  • CAS No. 4603-59-2

  • Cat. No. CS-0111913
  • Purity≥95%
  • MDL No.MFCD00234224

*For research and further manufacturing use only, not for direct human use.

3,6-Dimethoxypyridazine|CS-0111913

Structure of 4603-59-2

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General Information

  • CAS No. 4603-59-2
  • Cat. No. CS-0111913
  • Purity ≥95%
  • MDL No. MFCD00234224
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O₂
  • Molecular Weight 140.14
  • Synonym(s) Pyridazine,3,6-diMethoxy
  • SMILES COC1=NN=C(OC)C=C1

Description

3,6-Dimethoxypyridazine is a bench-stable, electron-deficient heterocycle featuring two methoxy groups at the 3- and 6-positions. This substitution pattern enhances solubility in polar organic solvents while maintaining reactivity for cross-coupling and nucleophilic displacement reactions. The molecule serves as a key scaffold in medicinal chemistry and agrochemical development.

Application

3,6-Dimethoxypyridazine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridazine scaffolds via cross-coupling and nucleophilic displacement reactions. Its methoxy groups enhance solubility and provide orthogonal reactivity for sequential functionalization. The compound exhibits excellent bench stability and facilitates purification by standard chromatographic methods, making it well-suited for high-throughput synthesis and API intermediate development.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      3,6-Dichloropyridazin|CS-0015357
      141-30-0
    • ~98%
    • In-stock
      3,6-Dimethoxypyridazine|CS-0111913
      4603-59-2

    References

    • ASTRAZENECA AB; ALHAMBRA, Cristobal; CHANG, Hui-Fang (Amy); CHAPDELAINE, Marc; HERZOG, Keith, John; SCHMIESING, Richard, J Patent: WO2011/21979 A1, 2011 ; Location in patent: Page/Page column 23 ; WO 2011/021979 A1
  • Route2
    • null|null
      67-56-1
    • In-stock
      3,6-Dichloropyridazin|CS-0015357
      141-30-0
    • null|null
      124-41-4
    • ~99%
    • In-stock
      3,6-Dimethoxypyridazine|CS-0111913
      4603-59-2

    References

    • ASTRAZENECA AB Patent: US2008/318943 A1, 2008 ; Location in patent: Page/Page column 73 ; US 20080318943 A1
  • Route3
    • null|null
      75-77-4
    • 4-Iodo-3,6-dimethoxy-pyridazine|CS-0195200
      262353-13-9
    • ~27%
    • In-stock
      3,6-Dimethoxypyridazine|CS-0111913
      4603-59-2
    • null|null
      126327-65-9

    References

    • Lepretre; Turck; Ple; Knochel; Queguiner Tetrahedron, 2000 , vol. 56, # 2 p. 265 - 273

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   44.24
  • LogP   0.4938
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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