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Structure of 457639-26-8
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2,5-Dimethyl-celecoxib (CAS 457639-26-8) blocks prostaglandin E2 synthesis by selectively inhibiting cyclooxygenase-2 activity while modulating transforming growth factor-β2 signaling. It suppresses COX-2 expression in inflammatory pathways. Researchers use this compound to probe pro-oxidative stress mechanisms in metastatic melanoma and breast cancer cells, revealing its potential cytotoxic effects. Its interaction with silymarin in rat osteoarthritis models further highlights synergistic anti-inflammatory action.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: