Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Methyl 2-fluoroisonicotinate

  • CAS No. 455-69-6

  • Cat. No. CS-0043947
  • Purity≥98%
  • MDL No.MFCD11656063

*For research and further manufacturing use only, not for direct human use.

Methyl 2-fluoroisonicotinate|CS-0043947

Structure of 455-69-6

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 455-69-6
  • Cat. No. CS-0043947
  • Purity ≥98%
  • MDL No. MFCD11656063
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO₂
  • Molecular Weight 155.13
  • Synonym(s) Methyl 2-fluoropyridine-4-carboxylate
  • SMILES O=C(OC)C1=CC=NC(F)=C1

Description

Methyl 2-fluoroisonicotinate is a fluorinated pyridine ester featuring a strategically positioned fluoro substituent at the 2-position. This electron-deficient heterocycle enables direct functionalization in cross-coupling reactions and serves as a key building block for bioactive molecules. The methyl ester group offers enhanced stability and facilitates downstream transformations.

Application

Methyl 2-fluoroisonicotinate serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its ortho-fluorinated pyridine core exhibits enhanced metabolic stability and modulated electronic properties, facilitating C–H functionalization and Suzuki-Miyaura coupling reactions. The ester group allows for selective transformations, while the molecule demonstrates excellent bench stability and compatibility with standard purification techniques.

Synthesis

  • Route1
    • Methyl isonicotinate Topiroxostat  Impurity|CS-0229355
      2459-09-8
    • ~61%
    • In-stock
      Methyl 2-fluoroisonicotinate|CS-0043947
      455-69-6

    References

    • Puy, Michael Van Der Tetrahedron Letters, 1987 , vol. 28, # 3 p. 255 - 258
  • Route2

    References

    • Roe et al. Journal of the American Chemical Society, 1949 , vol. 71, p. 4152
  • Route3

    References

    • Roe et al. Journal of the American Chemical Society, 1949 , vol. 71, p. 4152

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.0073
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • Methyl 2-fluoroisonicotinate sigmaMethyl 2-fluoroisonicotinate manufacturerMethyl 2-fluoroisonicotinate priceMethyl 2-fluoroisonicotinate structureMethyl 2-fluoroisonicotinate SDSbuy Methyl 2-fluoroisonicotinateMethyl 2-fluoroisonicotinate supplierMethyl 2-fluoroisonicotinate usesMethyl 2-fluoroisonicotinate molecular weightprice of Methyl 2-fluoroisonicotinateMethyl 2-fluoroisonicotinate chemical name formula of Methyl 2-fluoroisonicotinate
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label