Lot numbers can be found on the outside label of a product:
(2-Fluoropyridin-4-yl)methanol
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CAS No. 131747-60-9
- Cat. No. CS-W006245
- Purity≥98%
- MDL No.MFCD06200782
*For research and further manufacturing use only, not for direct human use.
Structure of 131747-60-9
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General Information
- CAS No. 131747-60-9
- Cat. No. CS-W006245
- Purity ≥98%
- MDL No. MFCD06200782
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₆FNO
- Molecular Weight 127.12
- Synonym(s) 4-Pyridinemethanol,2-fluoro-
- SMILES OCC1=CC(F)=NC=C1
Description
This fluorinated pyridine derivative features a reactive hydroxymethyl group at the 4-position, enabling straightforward functionalization. The electron-deficient pyridine ring enhances electrophilic reactivity, while the fluorine substituent imparts metabolic stability and modulates electronic properties. Ideal for medicinal chemistry applications requiring polar, rigid scaffolds with tunable solubility and bioavailability.
Application
(2-Fluoropyridin-4-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient incorporation of fluorinated pyridine motifs into target molecules. Its benzylic alcohol functionality facilitates straightforward derivatization—such as oxidation to the carboxylic acid or activation for coupling reactions—while maintaining compatibility with diverse reaction conditions. The molecule exhibits good bench stability and is readily purified by standard chromatographic methods, making it well-suited for use in multi-step synthesis and API development workflows.
Synthesis
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Route1
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1006300-11-3 - ~95%
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In-stock
131747-60-9
References
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Mitchell, Michael L.; Son, Jong Chan; Lee, Ill Young; Lee, Chong-Kyo; Kim, Hae Soo; Guo, Hongyan; Wang, Jianhong; Hayes, Jaclyn; Wang, Michael; Paul, Amber; Lansdon, Eric B.; Chen, James M.; Eisenberg, Gene; Geleziunas, Romas; Xu, Lianhong; Kim, Choung U. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 5 p. 1585 - 1588
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Route2
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123412-95-3 - ~52%
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In-stock
131747-60-9
References
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Maisonial, Aurelie; Kuhnast, Bertrand; Papon, Janine; Boisgard, Raphael; Bayle, Martine; Vidal, Aurelien; Auzeloux, Philippe; Rbah, Latifa; Bonnet-Duquennoy, Mathilde; Miot-Noirault, Elisabeth; Galmier, Marie-Josephe; Borel, Michele; Askienazy, Serge; Dolle, Frederic; Tavitian, Bertrand; Madelmont, Jean-Claude; Moins, Nicole; Chezal, Jean-Michel Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 2745 - 2766
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Route3
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In-stock
402-65-3 - ~%
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In-stock
131747-60-9
References
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Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 33.12
- LogP 0.713
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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